Sciatica and Chymopapain
نویسندگان
چکیده
منابع مشابه
Mechanism of action of intradiscal chymopapain in the treatment of sciatica: a clinical, biochemical, and radiological study.
Seventeen patients with intractable sciatica due to prolapse of a lumbar disc, treated by intradiscal injection of chymopapain (chemonucleolysis) were studied. Analysis of serial 24 hour urine collections showed a significant increase in urinary glycosaminoglycan after chemonucleolysis. This was not detected in four patients undergoing routine discography. Enzymic analysis of urinary glycosamin...
متن کاملComputed tomography and chymopapain chemonucleolysis: preliminary findings.
Ten lumbar disk levels in nine patients were examined by computed tomography (CT) before and 6 weeks after chymopapain chemonucleolysis of herniated nucleus pulposus (HNP). Patient selection for chemonucleolysis was partly based on CT scans demonstrating morphologic HNP criteria favoring a successful treatment outcome. Posttreatment CT scans disclosed a measurable HNP size decrease of 1-3 mm at...
متن کاملSciatica.
The mundane malady sciatica has been known to physicians since antiquity.1 It is pain that radiates from the buttock downward along the course of the sciatic nerve,2 but the term has been used indiscriminately for a variety of back and leg symptoms. Although sciatica has several causes, Mixter and Barr extended previous observations to establish in 1934 that the principal source is compression ...
متن کاملIntervertebral disk-space infection after chymopapain injection.
Four patients who had received chymopapain injections for treatment of herniated lumbar disks were evaluated by computed tomography (CT) because of persistent low back pain and suspicion of infection. Irregularity of the vertebral end-plate and a mottled appearance of the vertebral bodies suggested the diagnosis of disk-space infection in all four cases. CT-guided biopsy of the disk space was p...
متن کاملAnaphylactic reaction to chymopapain injection: A review and anesthesia considerations
The Food and Drug Administration (FDA) recently has re-released chymopapain, an injectable proteolytic enzyme used as an alternative to lumbar laminectomy in selected patients. The reported success rate, over 800%, has inspired an increasing usage of chymopapain. However, there is a reported 1 % incidence of anaphylaxis upon injection of this drug. The authors describe the means of early recogn...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1984
ISSN: 0003-4967
DOI: 10.1136/ard.43.4.659